The spectrum of cognitive impairment in Lewy body diseases
Identifieur interne : 000381 ( Main/Exploration ); précédent : 000380; suivant : 000382The spectrum of cognitive impairment in Lewy body diseases
Auteurs : Jennifer G. Goldman [États-Unis] ; Caroline Williams-Gray [Royaume-Uni] ; Roger A. Barker [Royaume-Uni] ; John E. Duda [États-Unis] ; James E. Galvin [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- physiology : Cognition.
- physiopathology : Cognition Disorders, Dementia, Lewy Body Disease.
- psychology : Cognition Disorders, Dementia, Lewy Body Disease.
- Animals, Humans, Risk Factors.
Abstract
Cognitive impairment represents an important and often defining component of the clinical syndromes of Lewy body disorders: Parkinson’s disease and dementia with Lewy bodies. The spectrum of cognitive deficits in these Lewy body diseases encompasses a broad range of clinical features, severity of impairment, and timing of presentation. Cognitive dysfunction is now recognized to occur not only in more advanced Parkinson’s disease, but also in early, untreated patients, and even in those patients with pre-motor syndromes such as REM behavior disorder and hyposmia. In recent years, the concept of “mild cognitive impairment” as a transitional or pre-dementia state in Parkinson’s disease has emerged. While this has led to much research regarding the diagnosis, prognosis, and underlying neurobiology of mild cognitive impairment in Parkinson’s disease, it has also raised questions regarding the usefulness of this concept and its application in clinical and research settings. In addition, the conundrum of whether Parkinson’s disease dementia and dementia with Lewy bodies represent the same or different entities remains unresolved. While these disorders overlap in many aspects of their presentations and pathophysiology, they differ in other aspects such as timing of cognitive, behavioral, and motor symptoms, medication responses, and neuropathological contributions. This article examines the spectrum and evolution of cognitive impairment in Lewy body disorders and debates these controversial issues in the field using point-counterpoint approaches.
Url:
DOI: 10.1002/mds.25866
PubMed: 24757110
PubMed Central: 4126402
Affiliations:
- Royaume-Uni, États-Unis
- Angleterre, Angleterre de l'Est, Pennsylvanie, État de New York
- Cambridge
- Université de Cambridge
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Le document en format XML
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Goldman</name><affiliation wicri:level="1"><nlm:aff id="A1">Rush University, Department of Neurological Sciences, Chicago IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rush University, Department of Neurological Sciences, Chicago IL</wicri:regionArea><wicri:noRegion>Chicago IL</wicri:noRegion></affiliation></author><author><name sortKey="Williams Gray, Caroline" sort="Williams Gray, Caroline" uniqKey="Williams Gray C" first="Caroline" last="Williams-Gray">Caroline Williams-Gray</name><affiliation wicri:level="4"><nlm:aff id="A2">John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Barker, Roger A" sort="Barker, Roger A" uniqKey="Barker R" first="Roger A." last="Barker">Roger A. Barker</name><affiliation wicri:level="4"><nlm:aff id="A2">John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Duda, John E" sort="Duda, John E" uniqKey="Duda J" first="John E." last="Duda">John E. Duda</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Neurology, University of Pennsylvania Perelman School of Medicine and the Parkinson’s Disease Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Neurology, University of Pennsylvania Perelman School of Medicine and the Parkinson’s Disease Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Galvin, James E" sort="Galvin, James E" uniqKey="Galvin J" first="James E." last="Galvin">James E. 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The spectrum of cognitive deficits in these Lewy body diseases encompasses a broad range of clinical features, severity of impairment, and timing of presentation. Cognitive dysfunction is now recognized to occur not only in more advanced Parkinson’s disease, but also in early, untreated patients, and even in those patients with pre-motor syndromes such as REM behavior disorder and hyposmia. In recent years, the concept of “mild cognitive impairment” as a transitional or pre-dementia state in Parkinson’s disease has emerged. While this has led to much research regarding the diagnosis, prognosis, and underlying neurobiology of mild cognitive impairment in Parkinson’s disease, it has also raised questions regarding the usefulness of this concept and its application in clinical and research settings. In addition, the conundrum of whether Parkinson’s disease dementia and dementia with Lewy bodies represent the same or different entities remains unresolved. While these disorders overlap in many aspects of their presentations and pathophysiology, they differ in other aspects such as timing of cognitive, behavioral, and motor symptoms, medication responses, and neuropathological contributions. This article examines the spectrum and evolution of cognitive impairment in Lewy body disorders and debates these controversial issues in the field using point-counterpoint approaches.</p></div></front></TEI><affiliations><list><country><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Pennsylvanie</li><li>État de New York</li></region><settlement><li>Cambridge</li></settlement><orgName><li>Université de Cambridge</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Goldman, Jennifer G" sort="Goldman, Jennifer G" uniqKey="Goldman J" first="Jennifer G." last="Goldman">Jennifer G. Goldman</name></noRegion><name sortKey="Duda, John E" sort="Duda, John E" uniqKey="Duda J" first="John E." last="Duda">John E. Duda</name><name sortKey="Galvin, James E" sort="Galvin, James E" uniqKey="Galvin J" first="James E." last="Galvin">James E. Galvin</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Williams Gray, Caroline" sort="Williams Gray, Caroline" uniqKey="Williams Gray C" first="Caroline" last="Williams-Gray">Caroline Williams-Gray</name></region><name sortKey="Barker, Roger A" sort="Barker, Roger A" uniqKey="Barker R" first="Roger A." last="Barker">Roger A. Barker</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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